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Business travelers will find the perfect location to visit the Orlando Convention Center with plenty of restaurants around to entertain your business relations. Epic McD is conveniently located near all the attractions right off Interstate 4. Or maybe you just want to relax and cook, all our properties have fully equipped kitchens. You can relax by the pool or have an adventurous day at Universal. Most of our properties are located in the Vista Cay Resort, the ideal spot for families and business men. Or if you know your way around, you will love our location for all your adventures. If it's your first time in Florida, we'd love to share our tips and tricks. If you are in town for business, we can offer you the ideal workspot close to the Orlando convention center, so you will not lose any precious time during your business trip.įrom booking to check out, with over 10 years of travel experience in Florida, you can rest assured that you are in good hands. Epic is popular for their Center Console, Ski and Wakeboard, Bay, Runabout and. Offering Ballet, Jazz, Contemporary, Acro, Tap, Hip Hop, Musical Theatre, Circus Arts and Art. 485/mo Sundance Marine Grand Junction, CO 81505. 2019 Small business OF THE yEAR Come be Epic Join us for fine arts classes like never seen before here in Central Florida. All Florida Yacht Sales Deltona, FL 32738. ![]() ![]() Locate Epic boat dealers and find your boat at Boat Trader. All our properties are centrally located and close the main attractions. Find Epic boats for sale near you, including boat prices, photos, and more. We want to make sure your visit to Central Florida is memorable and Epic! As a guest you can leave all your worries and we’ll make sure you have nothing to worry about. Whether you visit the Orlando area for a short getaway or a long trip to visit the parks and attractions. ![]() The maximum number of Markets per village you can have would be 6 Markets since if you maxed Merchant Guilds in Educationit will increases the number of merchants per Market by 5 and that will gives you 30 Merchants total in your village (Those are enough for your village since they will provide you with all what you need from Markets) Unless you are a Trader player and your village is safe from enemy attacks.Inn gives the same effect in increasing Popularityas them but you must put Breweryaway from your Village Hallto not waste the effect of the other buildings.The only buildings that are built next to Village Hall are Hovelsand Entertainment Buildingsalongside with Decorative Buildingsbut Entertainment Buildingsare the most important since you need the maximum increase of popularity from them by being the closest to your Village Hall. ![]()
![]() Your backup might not necessarily be corrupt, however: the same error message is shown when your iTunes backup is not compatible with the device that is being restored. ITunes' corrupt backup error message Corrupt? Or maybe not. It's not too hard to get your data our: check out our guide on getting data out of a corrupt iPhone backup below, It can suck to find out that you have a corrupt backup only when trying to restore with iTunes. Every now and then, when iTunes is backing up your iOS, it may happen that this process fails without an error message. This first message is straightforward and tells you you're dealing with a corrupt backup. ITunes could not restore the iPhone because the backup was corrupt or not compatible with the iPhone that is being restored iTunes restore errors that indicate corruption ![]() Let's look at the cause and solution to each. There are a handful of errors you might get when a backup is corrupt. Don't disconnect the device whilst iTunes is making a backup!.Store the safety copy on another location on your computer, other than the default iTunes backup folder.Always make a copy of your iTunes backup before an update.However, there are best practices to follow to avoid losing precious photos or important contacts. Given the many ways an iTunes backup can become corrupt, it's difficult to prevent all instances of the problem. Can I avoid iTunes corrupting my iOS backup? Photos taken by a recent iPhone are typically a few megabytes each, and a typical backup could be north of 30GB. iPhone Backup Extractor will do this automatically for you. For example, running out of disk space in the middle of a backup, having a hard-drive fail (or Dropbox eating your files!), an iOS upgrade going wrong, or a power failure during the backup can each affect the backup in different ways.Ī good way to sanity check whether there's a decent amount of data in a backup is to check how large the folder is. Encrypted corrupt backups are trickier, especially if the "manifest files" are missing, as these describe how data in the backup was encrypted, and are essential for the decryption process.īackups can be corrupted to different extents. It's usually straightforward to recover data from an unencrypted corrupt iTunes backup. Trying - and failing - to restore the backup using iTunes is another indicator. If iPhone Backup Extractor doesn't recognise the backup, labels it incomplete, shows no available data, or suggest the backup was created a very long time ago - like ! - then it's likely there's a problem with the backup. It'll show your backup's status: if it says "Complete and encrypted" or "Complete and unencrypted" that's a good sign. The easiest way is to install the free version of iPhone Backup Extractor, and load your backup in it. How to tell if your iTunes backup is corrupt You've got a great chance of recovering corrupt backups automatically with iPhone Backup Extractor. Recovering data from a corrupt iTunes backup is difficult but not impossible, and messages like "backup is corrupt or not compatible with your iPhone that is being restored" don't mean your data is "irreversibly lost". ![]() ![]() Remote Management: The ability to manage your smartphone from your desktop is a game-changer, especially when multitasking. Versatility: From transferring data to sharing screens, the app offers a range of functions that cater to various needs. AdvantagesĮase of Use: The straightforward installation and user-friendly interface make ApowerMirror a joy to use. My personal experience with the app has been quite intriguing, providing me a new perspective on how we interact with our devices. In the digital era where phone screens have become an extended part of our lives, ApowerMirror APK Premium acts as a bridge connecting the smartphone's convenience with the PC's efficiency. ![]() My Experience and Take on ApowerMirror Full APK Personal Review in a Narrative Style Furthermore, it offers a unique opportunity to manage your smartphone from your desktop computer seamlessly, adding a new layer of convenience to your digital life. If you're concerned about losing cherished memories or important files on your smartphone, ApowerMirror comes to the rescue by letting you create backup copies with ease. The main menu offers a range of options, from transferring files, photos, music, videos, and documents, to sharing your entire screen with your PC. Key Features That Make ApowerMirror Stand Outįrom managing data to sharing your screen, ApowerMirror 1.7.88 Android APK offers a myriad of attractive features. With both devices connected to the same network, it's as simple as entering a PIN or scanning a QR code. Installation is a breeze - simply download ApowerMirror on both devices and pair them via WiFi. Its user-friendly interface lets you operate your Android on your desktop while utilizing the convenience of a keyboard and mouse. Overview of ApowerMirror APK For Android DownloadĪpowerMirror APK Latest Version is an advanced app that facilitates sharing your smartphone screen on your PC. If you've ever dreamt of interacting with your Android device on a larger, more user-friendly PC screen, using a keyboard and mouse, ApowerMirror is your ticket to that reality. Positioned as a superlative tool for screen sharing and phone management, this innovative app provides a seamless interface for you to project and manage your smartphone on your PC. Bringing your Smartphone to the Big Screen | A Comprehensive Review of ApowerMirrorĭelving into the vibrant and technologically advanced world of apps, one particular software has garnered significant attention recently - ApowerMirror APK. How do I know if my lithium ion battery is bad?.Technically they are cross-compatible if a CR2032 can fit into the spot for a CR1616, though this is very unlikely. We recommend using the same brand (or one with equivalent quality), which should give you the estimated battery life. The 3 Volt CR2025 coin cell battery lasts about 4 to 6 months with normal use. The CR2016, CR2025, and CR2032 cell batteries all have the same voltage.Ībout 4 to 6 months. The CR2016 and CR2032 are exchangeable with the CR2025, but users must consider space limitations. They usually both have the same voltage (3V), and assuming they fit in the case, they are interchangeable.Īlthough there are no exact equivalent batteries to the CR2025, there are multiple batteries that may act as suitable substitutions. A 2032 is 20mm in diameter, 3.2mm thick, and a 2025 is slightly thinner, at 2.5mm thick. On the other DL is the short abbreviation of the battery making company Duracell.Ģ032 and 2025 are literally the dimensions of the battery. ![]() All the batteries who have this chemical substance in their batteries they can use this abbreviation CR. Others : Home electrical appliances/Multi- functional printer/Electronic price tags, POS systemsĬomponent Datasheet CR2025 Coin Battery DatasheetĬR is the generic designation that is used by the entire batteries maker but lithium batteries are also having chromium. The output voltage is 3V so that you can also power your 3V devices, modules, electronic devices.Īutomotive:Smart Key/Keyless entry /Door sill strip These batteries are also used in many modules, such as the RTC module. However, due to the varying current and operating temperature of the system, this figure will not be accurate.Īs per the circuit diagram below, you can use the CR2025 battery to power a 3V DC motor. So for our application that consumes only 20mA, the battery should last for 163/20) 8.15 hours. This means that if we draw 163mA, then our battery will last for 1 hour and, similarly, if we draw 81.5mA, the battery will last for 2 hours. Then, in that case, the capacity of our battery is 163mAh. The battery life depends on many parameters, such as operating temperature, discharge current, dynamic loads, etc.īut let us assume, for the sake of simplicity, that we are powering a normal load that consumes a constant current of 20mA at 20☌. The CR2025 is a commonly used battery for portable electronic applications. With just 0.7mm of difference, for as long as either fits in the battery compartment, they can be used interchangeably with minimal effect.ĭo note that the 2025, being the thinner of the two, will have slightly less storage reserve and will typically not last as long as a 2032. The CR2025 and CR2032 are both 3V button cells, have identical diameters, but the 2032 is 3.2mm thick while the 2025 is 2.5mm thick. ![]() Other Coin Cell Batteries: CR2032, CR2016, CR1220 Lightweight, High Voltage and High Energy DensityĮquivalent for CR2025 Battery: DL2025, BR2025 ![]() Lithium button or coin cell batteries are a bit expensive than alkaline, but last longer, weigh less and have a wide operating temperature range. Therefore, 20mm is the diameter of CR2025, and 2.5mm is the thickness. The name defines the size of the battery as for CR2025, the first two digits are for the diameter and the second for the height or thickness of tenths of mm. They are generally of a compact size, 5-25mm in diameter and 1-6mm in height. ![]() Coin cell batteries like CR2025 have many uses, they are usually used for small portable electronics devices such as: This video shows how to test your coin battery to know if it's bad or not.ĬR2025 is a coin cell battery. “Yogscast was a big, well-known brand and so it has a specific perception for people. “We spun it out of Yogscast, but it’s a standalone business. That all led to the creation of Fourth Floor and continues to define what drives and differentiates the agency today, but its very quickly grown outside of its parent too. So one of the aims of Fourth Floor was to do that, to have an agency that understood the creative point of view and also understood the broader market.” At the end of the day it was ‘why don’t we set up our own agency and do it the right way’. We wanted to work with a specific kind of agency. “So we saw a real opportunity to do it right. And from my point of view, having worked in the industry for a long time, I didn’t feel they understood the games market at all either… They were just there to get a buck.” “Working with them we found that they didn’t understand the creative point of view, they didn’t understand how that content gets made, why it gets made. “The multi-channel networks were all breaking up, losing their importance, and we originally thought what would grow in their place would be creator-led companies like our own, but instead it was smaller commercial networks and standalone agencies who were brokering commercial deals between influencers and brands. Keith had been at Yogscast since 2013, largely as chief revenue officer, but it became clear the influencer marketing wasn’t evolving in the way he expected. Keith explains how the company came about. The reason for Fourth Floor’s strong line on finding this balance for influencer marketing comes out of its partnership with The Yogscast. ![]() “What is incumbent on all of us, is not to try and drive it into being performance marketing, because that will lead to bad content, that will lead to people turning off branded content in the same way they turned off display advertising and other performance channels.” It’s much more aligned to brand marketing. “I think there’s a lot of people trying to drive the prices down, who are trying to do influencer marketing like its performance marketing and it’s not. However, that acceptance depends on maintaining a balance between creators and brands – keeping the quality up – something that not every creative agency is doing says Keith. ![]() And if you get that right, with the partnership’s supporting the channel and new kinds of content, then there’s value for an audience there. “You know it’s supporting the channel… creating content that wouldn’t be there otherwise. ![]() ![]() “Branded content should add to the experience,” he states firmly. If your audience doesn’t want it, you shouldn’t carry on trying to find different ways to make them see it anyway,” Keith opines. “With The Yogscast audience, over 60 percent of people are using ad blockers. But he also sees key differences, allowing it to succeed where its predecessors have stumbled. Keith sees influencer marketing as the spiritual successor to traditional display advertising, whether that be the TV spot, the magazine page or the banner ad. To date though, as in many sectors, the advertising models of the digital era have struggled to support the huge expansion in content that digital formats have brought. The games industry needs great content around its titles – content that engages passionate audiences. A key to that success is the agency’s solid grounding in the games industry – and an awareness of the responsibility that it has to creator-led campaigns explains Rich Keith, managing director of Fourth Floor Creative. ![]() “There is nothing difficult in the world as long as you set your mind to it.” Even the most challenging obstacles can be overcome with consistent effort and determination over time. ![]() This proverb is about the power of persistence and patience. “Dripping water can penetrate the stone.” 鱼与熊掌,不可兼得 (yú yǔ xióng zhǎng, bù kě jiān dé)Īn often-quoted Chinese proverb serves as a reminder that we cannot have everything we desire in life and that we must often make choices and prioritise what is most important. “One cannot have both the fish and the bear’s paw.” 塞翁失马,焉知非福 (sài wēng shī mǎ, yān zhī fēi fú)Ī common Chinese saying that highlights the unpredictable nature of life and encourages us to remain optimistic in the face of adversity, as misfortunes may sometimes lead to unexpected blessings. “When the old man from the frontier lost his horse, how could he have known it would be a blessing in disguise?” This saying encourages us to take the first step toward success, no matter how daunting the journey may seem. “The journey of a thousand miles begins with one step.” We’ve gathered some of our favourite insightful Chinese proverbs about life, so you can better understand how these ideas still impact modern-day China, and maybe even gain some new bits of wisdom in the process. These ancient Chinese sayings provide profound insights into traditional values and beliefs, which can bring your learning to life while also being very cool for learning about Chinese culture. If you’re eager to learn more Chinese, look no further than the many fascinating proverbs passed down from generation to generation. Whether you’re starting out with learning Chinese or are already a proficient speaker, understanding these pearls of wisdom can help guide your thinking and give context to conversations, even if it’s just on a subconscious level. Want to enrich your Chinese-speaking life? Love having a handy little life-affirming quote in your vocab arsenal? As well as being extremely useful for daily use, Chinese proverbs and sayings can provide guidance as well as insight into the rich culture of China. Applying the lessons of Chinese proverbs, sayings, and quotes Famous Chinese proverbs and sayings ![]() ![]() Powered by the ESHA Research Database © 2018, ESHA Research, Inc. If you are following a special diet for medical reasons, be sure to consult with your primary care provider or a registered dietitian to better understand your personal nutrition needs. (-) Information is not currently available for this nutrient. (For example, it’s recommended that people following a heart-healthy diet eat less sodium on a daily basis compared to those following a standard diet.) Depending on your calorie needs or if you have a health condition, you may need more or less of particular nutrients. Per the Food and Drug Administration (FDA), the daily value is based on a standard 2,000 calorie diet. Cook on high pressure for 7 minutes, then let the pressure release naturally for 10 minutes. Seal the lid, making sure the vent knob is turned to sealing. ![]() Place the trivet in the pot and the acorn squash halves on top of it. Acorn Squash Bake in 350 F oven for 35 minutes or. A super versatile fall vegetable, acorn squash is delicious stuffed, pureed into soup, or tossed into salad or pasta - and of course theres squash casserole. Instant Pot: Pour a cup of water in the bottom of an Instant Pot (6-quart size or bigger). Take time browning the onions cooking them low and slow. Percent Daily Value (%DV) found on nutrition labels tells you how much a serving of a particular food or recipe contributes to each of those total recommended amounts. Directions Wild Rice Place all ingredients into an oven-safe baking dish and bake at 350 F for 25 minutes. Roasting the butternut squash with honey and a touch of salt intensifies the natural sweetness of the squash and caramelizes the honey. * Daily Values (DVs) are the recommended amounts of nutrients to consume each day. A fork should be able to easily pierce the squash and shred it.Nutrition information is calculated by a registered dietitian using an ingredient database but should be considered an estimate. Place your squash on a large baking sheet or in a baking dish, cut side up. For sweet, brush it with softened butter and sprinkle brown sugar and cinnamon all over it. For savory, drizzle it with some olive oil and sprinkle paprika or curry powder over it with some salt and pepper. Garnish with toasted squash seeds for crunch. Vegan soup for the win This creamy-tasting but dairy-free dish starts with roasted butternut squash, adds fresh ginger for a little heat and a swirl of coconut milk for creaminess. Using a chef’s knife, start on one side of the stem and cut straight through until the knife stops hitting resistance and you’ve cut through to the hollow middle. Choose if you would rather go the sweet or savory route with your acorn squash. Butternut Squash Soup With Coconut Milk and Ginger. Arrange a rack in the bottom third of the oven and heat the oven to 375F. After roasting, the skin on the squash will be soft and edible so there's no need to worry about peeling it if you choose not to, but if you do, the flesh separates from the skin easily after roasting.ĭress it up. ![]() If you prefer to eat this squash without the skin, you totally can! If you choose to remove it, we recommend waiting until after it cooks (if you’re serving it whole). Leave the skin on and cut into half moon slices or peel the skin off and cut into large cubes! At this point you can also cut the squash further if you don't want to serve them in halves. Don't toss the seeds, though! Just like you can with pumpkin, clean them off and roast the seeds for a perfect little snack. After you have your squash open, use a spoon to scrape out the seeds. Cut the squash in half lengthwise, cutting through where the stem used to be. This will make a flat surface for it to stand on instead of dangerously rolling around on your cutting board. To make it easier, cut the stem off and place squash cut side down on your cutting board. Here’s everything you need to know to cook it perfectly:Ĭut it in half. You can dress it up savory or sweet based on your main-the possibilities for this squash are endless. 3) Mix pumpkin puree, sugar, salt, and spices. Full of fiber, this squash is not only packed with nutrients, but its small size makes it far easier to cut open and work with. 1) Prepare the pumpkin puree by poking a few holes with a fork into the pumpkin. While we have plenty of love for all the types of squash, we think that acorn squash deserves its chance in the spotlight. When it comes to winter squash, butternut squash and pumpkin can get all the attention. In our previous study, we determined that blocking glutamine metabolism and/or inhibiting cytosolic aspartate delivery via knockdown of mitochondrial aspartate-glutamate carrier 1 (AGC1) impairs cell proliferation and tumor growth. In addition, glutamine is an important substrate for mitochondrial aspartate synthesis. Cells lacking mitochondrial respiration have low aspartate levels and slow proliferation. For example, one requirement for aspartate production is a suitable NAD +/NADH ratio. Therefore, endogenous aspartate synthesis can limit the growth of some tumors. Although aspartate is available in circulation, these levels are insufficient to trigger its uptake in most cells that lack the plasma membrane aspartate transporter SLC1A3. Intracellular aspartate levels correlate with the proliferation rate in cancer cells and are limiting for the growth of some tumors in vivo. Aspartate is also involved in several intracellular processes including, but not limited to, redox homeostasis and the urea cycle. Īspartate is a proteinogenic non-essential amino acid that is used for de novo synthesis of nucleotides and certain non-essential amino acids. Furthermore, asparagine levels or ASNS (asparagine synthetase) activity could also determine the metastatic capacity of breast cancers both in vivo and in vitro. Pyruvate was also shown to be an important mediator of metastatic niche formation through hydroxylation of collagen. In addition, proline catabolism is selectively important for the proliferation and colony formation of metastatic cells, and reduced Prodh (proline dehydrogenase) activity leads to impaired in vivo lung metastasis in mouse breast cancer tumors. Similarly, lactate uptake through MCT1 (monocarboxylate transporter 1) expression has no effect on primary tumor growth but improves the number of circulating tumor cells and promotes distant melanoma metastasis. Consistently, inhibition of the folate pathway using methotrexate or knockdown of either ALDH1L2 (aldehyde dehydrogenase 1 family member L2) or MTHFD1 (methylenetetrahydrofolate dehydrogenase) blocks melanoma metastasis in vivo via hindering the survival of circulating melanoma tumors while having no impact on subcutaneous tumor growth. For instance, antioxidants such as N-acetylcysteine (NAC) increase melanoma metastasis in mice, suggesting that suppressing oxidative stress is one requirement of distant metastasis. ![]() Although a definitive metabolic pattern that distinguishes metastatic from non-metastatic tumors has not yet been identified, there is evidence that certain metabolic pathways could be more important for metastasis formation. In addition to the bioenergetics and biosynthetic demands of cell proliferation, metastatic cells also need to adapt their metabolism to succeed in the different steps of this cascade of events. To form metastasis, cancer cells follow a cascade of events including invading the surrounding tissue, detaching from the primary tumor, surviving in the circulation, and colonizing a distant organ. Surgical removal of the metastatic tumors from one or more organs is challenging, and drug-resistance, induced by the new tissue environment, may occur in metastatic tumors. Tumor metastasis is correlated with poor prognosis. In addition, it also argues that commonly known metastasis indicators, including EMT genes, cell migration, or colony formation, do not always reflect metastatic capacity in vivo. This study highlights that certain branches of metabolism impact tumor growth and tumor metastasis differently. On the other hand, conventional in vitro metastasis assays show no indication of increased metastasis capacity of AGC1-knockdown cells. AGC1-knockdown in mouse lung carcinoma and melanoma cell lines leads to increased pulmonary metastasis following subcutaneous or intravenous injections, respectively. Low AGC1 expression correlates with worse patient prognosis in many cancers. Here, we report the impact of AGC1-knockdown on metastasis. We previously described that loss-of-aspartate glutamate carrier 1 (SLC25A12 or AGC1), an important component of the malate-aspartate shuttle, impairs cytosolic aspartate levels, NAD +/NADH ratio, mitochondrial respiration, and tumor growth. However, the impact of intracellular aspartate levels on metastasis has not been studied. Aspartate biosynthesis and its delivery to the cytosol can be crucial for tumor growth in vivo. |
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